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2 edition of Pathogenesis of lithocholate induced intrahepatic cholestasis. found in the catalog.

Pathogenesis of lithocholate induced intrahepatic cholestasis.

Gary Kakis

Pathogenesis of lithocholate induced intrahepatic cholestasis.

by Gary Kakis

  • 101 Want to read
  • 14 Currently reading

Published .
Written in English


The Physical Object
Pagination258 leaves
Number of Pages258
ID Numbers
Open LibraryOL14581252M

  Pathophysiology of Drug-induced Cholestasis. Prior to their adverse action on hepatocytes, drugs need to be taken up into the cells. A large variety of . The intrahepatic cholestasis of pregnancy (ICP) is a multifactorial liver disorder which pathogenesis involves the interplay among abnormal bile acid (BA) levels, sex hormones, environmental.

  Hämäläinen ST, Turunen K, Mattila KJ, Sumanen M. Intrahepatic cholestasis of pregnancy and associated causes of death: a cohort study with follow-up of years. BMC Womens Health. Jun. Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis Article Feb

  Differential for bland cholestasis: drug induced liver injury (eg. anabolic steroids), early duct obstruction, benign recurrent intrahepatic cholestasis, acute cholestasis of pregnancy Differential for cholestatic hepatitis: primary sclerosing cholangitis (inflammation usually minimal), primary biliary cholangitis, viral hepatitis, large duct.   Intrahepatic cholestasis generally occurs at the level of the hepatocyte or biliary canalicular membrane. Causes include hepatocellular disease (eg, viral hepatitis, drug-induced hepatitis), drug.


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Pathogenesis of lithocholate induced intrahepatic cholestasis by Gary Kakis Download PDF EPUB FB2

Pathogenesis of lithocholate-induced intrahepatic cholestasis: Role of glucuronidation and hydroxylation of lithocholate Author links open overlay panel Dinh Duc Vu Beatriz Tuchweber Gabriel L. Plaa Ibrahim M. YousefCited by:   Pathogenesis of lithocholate-induced intrahepatic cholestasis: role of glucuronidation and hydroxylation of lithocholate.

Vu DD(1), Tuchweber B, Plaa GL, Yousef IM. Author information: (1)Department of Pharmacology, University of Montreal, by: 1. Gastroenterology. Oct;75(4) Pathogenesis of lithocholate- and taurolithocholate-induced intrahepatic cholestasis in rats.

Kakis G, Yousef by: Abstract. Lithocholic acid (LCA)-induced intrahepatic cholestasis is associated with increased de novo synthesis of hepatic cholesterol and augmented cholesterol content of the liver cell plasma membrane fraction enriched in bile canalicular complexes (BCM).Cited by: 6.

GASTROENTEROLOGY ; Lithocholate Cholestasis-Sulfated Glycolithocholate-Induced Intrahepatic Cholestasis in Rats I.M. YOUSEF, B. TUCHWEBER, R.J. VONK, D. MASS, M. AUDET, and C.C. ROY Centre de Recherche Pédiatrique, Hôpital Ste-Justine, and Départment de Nutrition, Université de Montréal, Montréal, Québec, Canada The intrahepatic cholestasis induced by Cited by: Kakis, G.

Yousef, I.M. Pathogenesis of lithocholate and taurolithocholate induced intrahepatic cholestasis in rats Gastroenterology () 2. Bonvicini, F. Gautier, A. Gandiol, D. Cholesterol in acute cholestasis induced by taurolithocholic acid Lab Invest () by:   The mechanism of lithocholateO-glucuronide-induced cholestasis is unknown.

In this study, we investigated the cholestatic effects of this agent in a congenital hyperbilirubinemic rat, EHBR. We also studied the effects of ursodeoxycholateO-glucuronide and tauroursodeoxycholate on lithocholateO-glucuronide-induced cholestasis in by:   The pathogenesis of intrahepatic cholestasis in rats was studied using isolated perfused livers as an experimental model.

Three basic mechanisms were differentiated: 1. Permeabilization of the bilio-sinusoidal barrier associated with electron microscopic alterations of the tight junctional complexes was found in livers of rats treated with α-naphthylisothiocyanate (ANIT, Cited by: Cholestasis syndromes characterised by impairment of bile formation and secretion arecaused by many diseases.

Estrogen-induced cholestasis among the cholestasis syndromes is a very common form. The bile dnctttlar reaction and peripheral cholestasis are also consequences of cholestasis. Although the pathogenesis of intra- hepatic cholestasis presented is hypo- thetical, it is clinically usefitl to reject mechanical obstruction in the intrahepatic bile duct system as the main mechanism and to accept damage of the hepatocytic bile secretory by:   Cristina Manzotti, Giovanni Casazza, Tea Stimac, Dimitrinka Nikolova, Christian Gluud, Total serum bile acids or serum bile acid profile, or both, for the diagnosis of intrahepatic cholestasis of pregnancy, Cochrane Database of Systematic Reviews, /CDpub2, ().

A number of liver disorders are specific to pregnancy. Amongst these, intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis (OC), is the commonest, affecting.

Kakis, M. Phillips and I. Yousef, The respective role of membrane cholesterol and of sodium potassium adenosine triphosphatase in the pathogenesis of lithocholate induced cholestasis,(). Google ScholarAuthor: Folkert Kuipers, Charles M. Bijleveld, C. Frank Kneepkens, John Fernandes, Roel J.

Vonk. Lithocholate Cholestasis-Sulfated Glycolithocholate-Induced Intrahepatic Cholestasis in Rats I.M. YOUSEF, B. TUCHWEBER, R.J. VONK, D. MASSE, M. AUDET, and C.C. ROY understanding of the pathogenesis of secretory fail- ure by the liver. The mechanisms involved in LCA cholestasis have been discussed in previous publications.

Intrahepatic cholestasis, defined as arrested bile flow, mimics extrahepatic obstruction in its biochemical, clinical and morphological features.

Kakis G, Yousef IM () Pathogenesis of lithocholate and taurolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology – PubMed Google Scholar Milligram doses of [3H]lithocholate glucuronide resulted in partial or complete cholestasis.

When induced cholestasis was partial, secretion in bile remained the primary excretory route (% recovery in bile), while, when complete cholestasis was induced, wide tissue distribution of Cited by:   Milligram doses of [3H]lithocholate glucuronide resulted in partial or complete cholestasis.

When induced cholestasis was partial, secretion in bile remained the primary excretory route (% recovery in bile), while, when complete cholestasis was induced, wide tissue distribution of radiolabel was by: Sepsis-induced cholestasis is a complication of infection.

Infections cause systemic and intrahepatic increase in proinflammatory cytokines which result in impaired bile flow ie. cholestasis. Several other mediators of impairment in bile flow have been identified under conditions of sepsis such as increased nitric oxide production and decreased aquaporin by: Of note, heterozygous mutations of ABCB4 are implicated in a spectrum of cholestatic liver disease, including inherited diseases such as low-phospholipid associated cholelithiasis (LPAC) syndrome, and acquired cholestasis such as drug-induced liver by:.

This book has the stated aim “to provide a cutting-edge overview on the molecular pathogenesis of cholestasis.” To achieve this aim, the editors solicited 25 chapters from colleagues who have contributed to the explosion of new information and concepts in hepatocellular and cholangiocytic transport and their impairment in cholestatic : Alan F.

Hofmann. Kakis G, Phillips MJ, Yousef IM. The respective roles of membrane cholesterol and of sodium potassium adenosine triphosphatase in the pathogenesis of lithocholate-induced cholestasis.

Lab Invest. Jul; 43 (1)– King JE, Schoenfield LJ. Cholestasis induced by sodium taurolithocholate in isolated hamster liver. J Clin Invest.

Roderick Houwen (Wilhelmina Children's Hospital, Utrecht, The Netherlands) discussed the clinical relevance of FIC1 (ATP8B1), the gene involved in various forms of intrahepatic cholestasis associated with FIC1 deficiency (PFIC type 1, Byler's disease, Greenland familial cholestasis, and benign recurrent intrahepatic cholestasis [BRIC] type 1 Cited by: